Thursday, February 28, 2013

Congo rebels clash near Goma after political chief sacked

KINSHASA (Reuters) - Heavy fighting broke out between two factions of Congo's M23 rebels near the eastern town of Goma on Thursday after one side said it sent men to arrest a leader of the other who is wanted by the International Criminal Court (ICC).

The M23 military commander said earlier that the M23 political coordinator Jean-Marie Runiga had been sacked, underlining infighting likely to undermine regional efforts to end two decades of conflict in central Africa.

The M23 rebellion is the latest uprising in Democratic Republic of Congo's mineral rich eastern borderlands. Last year the group inflicted a series of defeats on government forces, culminating in the brief seizure of the major town of Goma.

The emerging power struggle within rebel ranks will further damage efforts to resuscitate peace talks hosted by Uganda and may spur the Kinshasa government to push for a military solution to recurring rebellions in the east.

A Reuters witness in Goma said heavy weapons fire could be heard coming from the direction of rebel positions around Kibumba, some 25 km (14 miles) north of Goma.

"They attacked us so we reacted," said Colonel Seraphin Mirindi, spokesman for the M23 rebel faction loyal to Runiga.

Eight people were killed in clashes between M23 factions earlier this week.

In an earlier statement, the M23 military command said Runiga was ousted for stealing money and backing the rebel faction loyal to Bosco Ntaganda, a fighter wanted by the ICC on charges of killing civilians during a previous uprising.

The statement, signed by military commander Sultani Makenga, said Makenga would become the group's interim leader.

Runiga was unavailable for comment. He told Reuters on Wednesday there were no problems between himself and Makenga.

MOVE TO ARREST ICC SUSPECT

M23 spokesman and Makenga loyalist Colonel Vianney Kazarama said fighters had been dispatched to arrest Ntaganda, believed to be just 20 km (15 miles) north of Goma, on Thursday.

Mirindi, a pro-Ntaganda member of the group, warned: "We have the right to defend ourselves."

U.N. experts say Ntaganda has played a major command role within M23. This has been denied by the rebels.

"We'll see who emerges from this the winner," Thierry Vircoulon, Central Africa project director for the International Crisis Group think tank, said of the power struggle.

"I wouldn't say there's a good guy and a bad guy, but there's one who is more manageable, and the other who is wanted by the ICC. It's another argument for Kinshasa to perhaps go for the military option."

Goma's seizure in November embarrassed Congo's government and U.N. peacekeepers deployed to support Kinshasa's forces.

U.N. experts accused neighbouring Rwanda of backing the rebels. Kigali, which has repeatedly intervened in chaotic Congo's conflicts since Rwandan Hutu rebels sought refuge in the lawless east after the 1994 genocide, denied the charge.

Donors slashed millions of dollars in aid to Rwanda as a result. But there has been only slow progress since towards deploying a 4,000-strong international force to hunt down an array of rebel groups still operating in Congo.

Hundreds of thousands of people fled last year's violence, the latest in series of Tutsi-led rebellions whose roots can be traced to the aftermath of Rwanda's genocide and a cross-border web of ethnic, business and political interests.

African leaders signed a U.N.-mediated deal on Sunday paving the way for the deployment of military brigades.

But, having seen numerous other initiatives fail, there is scepticism whether the deal can remove the patchwork of rebel groups and pro-government militias that roam the east.

"The only situation that will make the government happy is the disappearance of politico-military movements like M23," said Congolese government spokesman Lambert Mende.

Source: http://news.yahoo.com/congo-rebels-sack-political-chief-splits-undermine-peace-101613436.html

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Marines T-shirt a no-no at Illinois school

A father wants an Illinois school district to rethink its dress code after his son was threatened with suspension if he did not remove his U.S. Marines T-shirt.

According to FoxNews.com, Daniel McIntyre, 44, said his 14-year-old son was told by his teacher Karen Deverell during reading class at Genoa-Kingston Middle School on Monday that his shirt violated the dress code because it shows two interlocking guns. He was then asked to wear the shirt inside out or face possible suspension.

?My son is very proud of the Marines and, in fact, of all the services,? McIntyre said. ?So he wears it with pride. There are two rifles crossed underneath the word ?Marines? on the shirt, but to me that should be overlooked. It?s more about the Marines instead of the rifles.?

McIntyre said his son had worn the shirt plenty of times to school. Deverell did not inform school officials of the incident, but when asked about school dress policy, Genoa-Kingston Superintendent Joe Burgess said the T-shirt was not a violation. He added that the school dress policy simply requires kids to dress in a ?neat, clean and well-fitting manner,? and avoid wearing gang symbols or clothing that promotes ?violent behavior.? The code does not specifically ban images of guns.

A statement obtained by FoxNews.com reads in part, ?The administration and school handbook agree that this shirt is not a violation of the dress code. We also take school safety very earnestly and it needs to be recognized that is a topic that we also take very seriously and support our students and staff in providing a safe environment to learn, teach and work in on a daily basis.?

Meanwhile, McIntyre is asking that the code be updated. ?This is not right. This policy that they have in place can obviously be loosely interpreted, so they need to change it.?

Source: http://news.yahoo.com/blogs/lookout/father-asks-school-rethink-dress-code-son-told-180721078.html

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Amazon Cloud Player for iOS arrives on the iPad

Amazon Cloud Player for iOS arrives on the iPad

As timely updates go, this one's a bit long in the tooth. After introducing its Cloud Player for iOS to the iPhone and iPod touch last summer, Amazon's finally gotten around to rolling out a version for iPad owners. The updated app, which is seeing a version bump to 2.0, now sports a tweaked UI and a cache size management tool. Other than that, it's still the same "free" streaming music service, offering 5GB of complementary storage, access to Amazon mp3 purchases (AutoRip CDs included) and any AAC-tracks from your current iTunes library. You can grab it now at the source below. Go ahead, it might mend Norah's little broken heart(s).

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Source: iTunes

Source: http://www.engadget.com/2013/02/27/amazon-cloud-player-for-ios-arrives-on-the-ipad/

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Researchers explore PKC role in lung disease

Tuesday, February 26, 2013
A JGP study examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases. The diagram shown summarizes the pathways regulating airway smooth muscle contraction. Credit: Dixon, R.E., and L.F. Santana. 2013. J. Gen. Physiol. appear in The Journal of General Physiology, provide new insight into the mechanisms involved in regulating luminal diameter of small airways and reveal PKC as a potential target for drug therapies.

The researchers used phase-contrast video microscopy, confocal microscopy, Western blot analysis, and pharmacological activators and inhibitors to investigate the role of PKC in airway SMC contraction in mouse lung slices. Their results suggest that activation of PKC in small airways promotes an influx of calcium into SMC and subsequent intracellular release of calcium ions to generate low frequency SMC twitching. PKC activation also induces a strong calcium ion sensitization of contraction, eliciting a stronger contractile response to stimuli that increase free intracellular calcium. Consequently, PKC activation downstream of various molecules, such as thrombin, that are present in the airways in conjunction with inflammatory lung diseases, could sensitize the airway SMCs to contractile stimuli and contribute to the airway hyper responsiveness that is characteristic of asthma and COPD.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 35 time(s).

Source: http://www.labspaces.net/127020/Researchers_explore_PKC_role_in_lung_disease_

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Wednesday, February 27, 2013

After meatballs, Ikea withdraws sausages

Lenka Cernikova takes samples of food to test it on traces of horse meat in a widening European food labeling scandal at a veterinary laboratory in Prague, Czech Republic, Wednesday, Feb. 27, 2013. Horse meat has turned up across Europe in frozen supermarket meals such as burgers and lasagna, in beef pasta sauce, on restaurant menus, in school lunches and in hospital meals. (AP Photo/Petr David Josek)

Lenka Cernikova takes samples of food to test it on traces of horse meat in a widening European food labeling scandal at a veterinary laboratory in Prague, Czech Republic, Wednesday, Feb. 27, 2013. Horse meat has turned up across Europe in frozen supermarket meals such as burgers and lasagna, in beef pasta sauce, on restaurant menus, in school lunches and in hospital meals. (AP Photo/Petr David Josek)

Lenka Cernikova prepares samples of food to test it on traces of horse meat in a widening European food labeling scandal at a veterinary laboratory in Prague, Czech Republic, Wednesday, Feb. 27, 2013. Horse meat has turned up across Europe in frozen supermarket meals such as burgers and lasagna, in beef pasta sauce, on restaurant menus, in school lunches and in hospital meals. (AP Photo/Petr David Josek)

Lenka Cernikova takes samples of food to test it on traces of horse meat in a widening European food labeling scandal at a veterinary laboratory in Prague, Czech Republic, Wednesday, Feb. 27, 2013. Horse meat has turned up across Europe in frozen supermarket meals such as burgers and lasagna, in beef pasta sauce, on restaurant menus, in school lunches and in hospital meals. (AP Photo/Petr David Josek)

Lenka Cernikova takes samples of food to test it on traces of horse meat in a widening European food labeling scandal at a veterinary laboratory in Prague, Czech Republic, Wednesday, Feb. 27, 2013. Horse meat has turned up across Europe in frozen supermarket meals such as burgers and lasagna, in beef pasta sauce, on restaurant menus, in school lunches and in hospital meals. (AP Photo/Petr David Josek)

STOCKHOLM (AP) ? After withdrawing meatballs from stores across Europe, home furnishings company Ikea said Wednesday its own tests confirmed "a few indications of horse meat" and that it would also remove wiener sausages made by the same supplier.

Ikea said it would withdraw the sausages from stores in France, Britain, Spain, Ireland and Portugal. Other stores were getting sausages from other suppliers, company spokeswoman Ylva Magnusson said.

No horse meat had been found in the wieners, which are made of ground pork and beef, but they were removed anyway because they came from the same supplier as the meatballs, Magnusson said.

The supplier, Gunnar Dafgard AB, didn't return calls seeking comment.

The move comes two days after Czech food inspectors found traces of horse meat in Ikea's Swedish-made meatballs, prompting the company to pull them from store shelves in 21 European countries and in Hong Kong, Thailand and the Dominican Republic.

Stores in other countries, including the U.S. and Canada, were not affected because they received meatballs from a different supplier.

Ikea said results from its own tests confirmed some meatballs didn't just contain beef and pork, despite what their labeling said.

"Based on some hundred test results that we have received so far, there are a few indications of horse meat," Magnusson said. "Together with the Swedish supplier in question we have decided to withdraw from sales also the wiener sausages ... from that supplier."

Horse meat has recently been found mixed into beef dishes sold across Europe, including in frozen supermarket meals. It has also been found in meals served at restaurants, schools and hospitals. Authorities say the scandal is a case of fraudulent labeling but does not pose a health risk.

The French wholesaler at the epicenter of the scandal, Spanghero, announced Wednesday that it had filed for bankruptcy protection. The company denies that it intentionally mislabeled and sold horse meat as beef, but the French government has said it should have known and temporarily forced it to shut down all production. It has slowly started to package meats again, but is not selling any to other manufacturers.

The company, which employs about 300 people, said it hoped the court filing would save its business and those jobs.

Meanwhile, food safety authorities across Europe continued to clamp down on mislabeled meat.

Latvia's food safety agency said that traces of horse meat were found in products labeled as beef by a local meatpacker, Forevers.

The agency said 416 horses were slaughtered last year in Latvia, out of which 203 were eventually delivered to Forevers from the same Latvia-based slaughterhouse, Aibi. All the horse meat was labeled as beef in the invoices, the agency said. It wasn't immediately clear if any of the meat was exported.

Also Wednesday, Russia's state sanitary watchdog said it detected horse meat in sausages imported from Austria. The agency's spokesman, Alexei Alexeyenko, said in a statement carried by the ITAR-Tass news agency that the sausages were stated to only contain beef.

Portuguese authorities said late Tuesday they had seized 79 metric tons (87 U.S. tons) of beef products containing traces of horse meat in recent days and opened criminal proceedings against five local companies. Portugal's Food Safety Agency said it made the seizures at companies that process, package and distribute meat to large retail outlets.

The agency said in a statement on its website that it also took almost 19,000 pre-packed products from Portuguese stores after detecting horse meat in them. They included lasagnas, hamburgers and meatballs.

___

Associated Press writers Barry Hatton in Lisbon, Sarah DiLorenzo in Paris, Gary Peach in Riga, Latvia; and Vladimir Isachenkov in Moscow contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-27-Europe-Horse%20Meat/id-a8a7892f097f4e68aa78482554fc7031

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Senate confirms Hagel for defense secretary

FILE - In this Jan. 31, 2013, file photo, Secretary of Defense nominee Chuck Hagel testifies before the Senate Armed Services Committee during his confirmation hearing on Capitol Hill in Washington. A deeply divided Senate is moving toward a vote on President Barack Obama?s contentious choice of Chuck Hagel to head the Defense Department, with the former Republican senator on track to win confirmation after a protracted political fight. (AP Photo/J. Scott Applewhite, file)

FILE - In this Jan. 31, 2013, file photo, Secretary of Defense nominee Chuck Hagel testifies before the Senate Armed Services Committee during his confirmation hearing on Capitol Hill in Washington. A deeply divided Senate is moving toward a vote on President Barack Obama?s contentious choice of Chuck Hagel to head the Defense Department, with the former Republican senator on track to win confirmation after a protracted political fight. (AP Photo/J. Scott Applewhite, file)

(AP) ? The Senate has voted to confirm Chuck Hagel to be the nation's next defense secretary.

The vote Tuesday was 58-41, with four Republicans joining Democrats in backing President Barack Obama's nominee.

The vote ended a contentious fight over the president's choice for his second-term national security team.

Republicans opposed the former two-term Republican senator from Nebraska, casting him as out of the mainstream and overly critical of Israel. But Democrats stood together for Hagel, a twice-wounded Vietnam combat veteran.

Hagel will succeed Defense Secretary Leon Panetta, who is stepping down after four years as CIA director and Pentagon chief.

The vote came just hours after Republicans dropped their delay and allowed the nomination to move forward. The Senate vote to end the filibuster was 71-27.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-02-26-Hagel/id-26ac6b9740994e62a5be79453f8ff15b

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Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer

Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA An increasing body mass index was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"We know that exercise and avoiding obesity decrease colorectal cancer risk, but little is known about why," said Shuji Ogino, M.D., Ph.D., associate professor of pathology at Dana-Farber Cancer Institute and associate professor in the Department of Epidemiology at Harvard School of Public Health in Boston, Mass. "In this study, we used a biomarker named CTNNB1, which is a molecule implicated in cancer and obesity, to divide patients into two groups, CTNNB1-positive and CTNNB1-negative."

Ogino and colleagues used data from more than 100,000 women from the Nurses' Health Study and more than 45,000 men in the Health Professionals Study to examine whether there was an association between body mass index (BMI) or exercise activity and colorectal cancer risk according to CTNNB1 expression status.

Among the study population, 2,263 individuals were diagnosed with colorectal cancer during follow-up. Tumor CTNNB1 expression data were available for 861 of these individuals, and 54 percent of these tumors were negative for CTNNB1 and 46 percent positive for the biomarker.

Increasing BMI by a 5.0 kg/m2 increment was associated with a 34 percent higher risk for CTNNB1-negative cancer, but was not associated with CTNNB1-positive cancer. In contrast, increasing physical activity level was associated with a significantly lower risk for CTNNB1-negative cancer. It was not associated with CTNNB1-positive cancer.

"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Ogino said. "If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity."

In addition, the data indicated that CTNNB1 could be a potential target for chemoprevention and treatment, according to Ogino. He called for more population-based, large-scale databases to facilitate molecular pathological epidemiology research.

"Currently, most population-based studies do not take tumor heterogeneity into consideration, and typically colon cancer is treated as a single disease," Ogino said. "We need to integrate molecular pathology and epidemiology in education and research to facilitate integrative science and improve public health."

###

Follow the AACR on Twitter: @aacr -

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the American Association for Cancer Research

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit www.AACR.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA An increasing body mass index was associated with a higher risk for colorectal cancer with a specific molecular characteristic, and inversely, physical activity was linked to a decreased risk for that same cancer, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"We know that exercise and avoiding obesity decrease colorectal cancer risk, but little is known about why," said Shuji Ogino, M.D., Ph.D., associate professor of pathology at Dana-Farber Cancer Institute and associate professor in the Department of Epidemiology at Harvard School of Public Health in Boston, Mass. "In this study, we used a biomarker named CTNNB1, which is a molecule implicated in cancer and obesity, to divide patients into two groups, CTNNB1-positive and CTNNB1-negative."

Ogino and colleagues used data from more than 100,000 women from the Nurses' Health Study and more than 45,000 men in the Health Professionals Study to examine whether there was an association between body mass index (BMI) or exercise activity and colorectal cancer risk according to CTNNB1 expression status.

Among the study population, 2,263 individuals were diagnosed with colorectal cancer during follow-up. Tumor CTNNB1 expression data were available for 861 of these individuals, and 54 percent of these tumors were negative for CTNNB1 and 46 percent positive for the biomarker.

Increasing BMI by a 5.0 kg/m2 increment was associated with a 34 percent higher risk for CTNNB1-negative cancer, but was not associated with CTNNB1-positive cancer. In contrast, increasing physical activity level was associated with a significantly lower risk for CTNNB1-negative cancer. It was not associated with CTNNB1-positive cancer.

"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Ogino said. "If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity."

In addition, the data indicated that CTNNB1 could be a potential target for chemoprevention and treatment, according to Ogino. He called for more population-based, large-scale databases to facilitate molecular pathological epidemiology research.

"Currently, most population-based studies do not take tumor heterogeneity into consideration, and typically colon cancer is treated as a single disease," Ogino said. "We need to integrate molecular pathology and epidemiology in education and research to facilitate integrative science and improve public health."

###

Follow the AACR on Twitter: @aacr -

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the American Association for Cancer Research

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes eight peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer. For more information about the AACR, visit www.AACR.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/aafc-opi022013.php

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Study reveals stem cells in a human parasite

Tuesday, February 26, 2013

From the point of view of its ultimate (human) host, the parasitic flatworm Schistosoma mansoni has a gruesome way of life. It hatches in feces-tainted water, grows into a larva in the body of a snail and then burrows through human skin to take up residence in the veins. Once there, it grows into an adult, mates and, if it's female, starts laying eggs. It can remain in the body for decades.

A new study offers insight into the cellular operations that give this flatworm its extraordinary staying power. The researchers, from the University of Illinois, demonstrated for the first time that S. mansoni harbors adult, non-sexual stem cells that can migrate to various parts of its body and replenish tissues. Their report appears in the journal Nature.

According to the World Health Organization, more than 230 million people are in need of treatment for Schistosoma infections every year. Most live in impoverished areas with little or no access to clean water. Infection with the worm (also known as a blood fluke) can lead to damaging inflammation spurred by the presence of the worm's eggs in human organs and tissues.

"The female lays eggs more or less continuously, on the order of hundreds of eggs per day," said U. of I. cell and developmental biology professor and Howard Hughes Medical Institute Investigator Phillip Newmark, who led the study with postdoctoral researcher James J. Collins III.

"The eggs that don't get excreted in the feces to continue the life cycle actually become embedded inside host tissues, typically the liver, and those eggs trigger a massive inflammatory response that leads to tissue damage."

Children are especially vulnerable to the effects of infection, in some cases experiencing delays in growth and brain development as a result of chronic inflammation brought on by the parasites.

The new study began with an insight stemming from years of work on a different flatworm, the planarian, in Newmark's lab. Collins thought that schistosomes might make use of the same kinds of stem cells (called neoblasts in planarians) that allow planarians to regenerate new body parts and organs from even tiny fragments of living tissue.

"It just stood to reason that since schistosomes, like planaria, live so long that they must have a comparable type of system," Collins said. "And since these flatworms are related, it made sense that they would have similar types of cells. But it had never been shown."

In a series of experiments, Collins found that the schistosomes were loaded with proliferating cells that looked and behaved like planarian neoblasts, the cells that give them their amazing powers of regeneration. Like neoblasts, the undifferentiated cells in the schistosomes lived in the mesenchyme, a kind of loose connective tissue that surrounds the organs. And like neoblasts, these cells duplicated their DNA and divided to form two "daughter" cells, one of which copied its DNA again, a process that normally precedes cell division.

"Stem cells do two things," Newmark said. "They divide to make more stem cells and they give rise to cells that can differentiate."

Collins had labeled the cells with fluorescent markers. This allowed him to watch how they behaved. He noted that over the course of a few days, some of the labeled cells migrated into the gut or muscle, to become part of those tissues.

"We label the cells when they're born and then we see what they grow up to become," Collins said. "This is not conclusive evidence that these cells are equivalent to the planarian neoblasts, but it is consistent with the hypothesis that they are."

The researchers went deeper, determining which genes were turned on or off, up or down in the proliferating cells as compared with the non-dividing cells. They identified a gene in the proliferating cells that coded for a growth factor receptor very similar to one found in planarians. When the researchers switched off the parasite's ability to make use of this gene (using a technique called RNA interference in worms grown in the lab), the proliferating cells gradually died out.

"We postulated that these cells are important for the longevity of the parasite," Collins said. "Now we can start asking which genes regulate these cells."

"We started with the big question: How does a simple parasite survive in a host for decades?" Newmark said. "That implies that it has ways of repairing and maintaining its tissues. This study gives us insight into the really interesting biology of these parasites, and it may also open up new doors for making that life cycle a lot shorter."

###

University of Illinois at Urbana-Champaign: http://www.uiuc.edu

Thanks to University of Illinois at Urbana-Champaign for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 37 time(s).

Source: http://www.labspaces.net/127019/Study_reveals_stem_cells_in_a_human_parasite

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Google Settings app sneaks onto Android to bolster G+ Sign-In

Google Settings app sneaks onto Android to bolster G SignIn

If you're wondering what that pretty green icon is that may have popped up recently on your Android device, worry not -- it's just the new Settings app from Google. You can now access preferences from Maps, Google+ and Search from one place through the app, and also see which are hooked in to the new Google+ Sign-In system we saw yesterday. Google took the unusual step of installing the app without asking via a Google Play service update, and if you haven't seen it yet you can force the issue by going to the application manager, clearing the data from Google Play services and rebooting. With its various apps becoming more intertwined, it wouldn't be surprising if Google dumped more settings there in the future, so you may as well get a handle on it now.

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Via: Android Central

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/YdLd2XBNBZQ/

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Voters ponder guns, ethics in Jackson Jr. district

FILE - in this Feb. 20, 2013 file photo, former Illinois Rep. Jesse Jackson, Jr leaves federal court in Washington after he entered a guilty plea to criminal charges that he engaged in a scheme to spend $750,000 in campaign funds on personal items. Residents in Illinois' 2nd District are preparing to vote in a special primary Feb. 26 to replace Jackson in the Chicago area district that has seen three congressmen leave office in an ethical cloud. (AP Photo/Cliff Owen, File)

FILE - in this Feb. 20, 2013 file photo, former Illinois Rep. Jesse Jackson, Jr leaves federal court in Washington after he entered a guilty plea to criminal charges that he engaged in a scheme to spend $750,000 in campaign funds on personal items. Residents in Illinois' 2nd District are preparing to vote in a special primary Feb. 26 to replace Jackson in the Chicago area district that has seen three congressmen leave office in an ethical cloud. (AP Photo/Cliff Owen, File)

FILE - In this Feb. 7, 2013 file photo, former Illinois state Rep. Robin Kelly, accepts the endorsement at a Chicago news conference from left to right, Gail Mahome, Dr. Willie Wilson and Dr. John Gray, members of the International Ministers & Community Alliance, in her bid to replace former U.S. Jesse Jackson Jr., in Illinois' 2nd District. Residents in the 2nd District are preparing to vote in a special primary Feb. 26 to replace Jackson in the Chicago area district that has seen three congressmen leave office in an ethical cloud. Jackson entered a guilty plea in Washington, Feb. 20 to criminal charges that he engaged in a scheme to spend $750,000 in campaign funds on personal items. He resigned from Congress in November 2012. (AP Photo/M. Spencer Green, File)

FILE - In this Dec. 15, 2012 file photo, former Illinois Congressman Debbie Halvorson speaks during a candidate presentation at the 2nd District slating meeting in South Holland, Ill. Residents in Illinois 2nd District are preparing to vote in a special primary Feb. 26, 2013, to replace former Rep. Jesse Jackson Jr., in the Chicago area district that has seen three congressmen leave office in an ethical cloud. Jackson entered a guilty plea in Washington, Feb. 20 to criminal charges that he engaged in a scheme to spend $750,000 in campaign funds on personal items. He resigned from Congress in November 2012. (AP Photo/John Smierciak, File)

In this Feb. 7, 2013 photo, U.S. Congressional hopeful Chicago Alderman Anthony Beale speaks at a news conference in Chicago where Cook County Sheriff Tom Dart, left, endorsed him in his bid replace former U.S. Rep. Jesse Jackson Jr. in Illinois' 2nd District. Residents in the 2nd District are preparing to vote in a special primary Feb. 26 to replace Jackson in the Chicago area district that has seen three congressmen leave office in an ethical cloud. Jackson entered a guilty plea in Washington, Feb. 20 to criminal charges that he engaged in a scheme to spend $750,000 in campaign funds on personal items. He resigned in November 2012. (AP Photo/M. Spencer Green, File)

(AP) ? Candidates for Jesse Jackson Jr.'s former congressional seat made their final push for votes Monday ahead of a high-stakes primary, but turnout was expected to be paltry despite the lurid headlines surrounding the disgraced Chicago Democrat and millions in outside super PAC money driven largely by the guns debate.

The front-runners ? former state Rep. Robin Kelly, former U.S. Rep. Debbie Halvorson and Chicago Alderman Anthony Beale ? made a flurry stops at train stations, strip malls and diners all over the district that spans Chicago's South Side, south suburbs and some rural areas. They faced a truncated campaign season, the frenzy for endorsements once locked up by Jackson and even a potential Election Day winter storm.

But Danny Armstrong, 51, who had voted previously for Jackson, remained undecided between Beale and Kelly and was considering whether to even vote at all. Jackson pleaded guilty this month to illegally spending campaign funds and became the third consecutive congressman in the district to leave office under an ethical or legal cloud.

"I feel let down," said Armstrong, who works as a school bus aide and at a bowling alley.

Early voting numbers showed reluctance to get to the polls.

In Chicago, fewer than 2,800 voters, or roughly 2 percent of registered voters in the district, cast early ballots. In suburban Cook County ? the bulk of the district's voting population ? it was nearly 2 percent.

The last time the Chicago area had a special primary election for Congress was 2009 after Rahm Emanuel left his seat to take a job as White House chief of staff. Roughly 18 percent of registered Chicago voters in the district including North Side neighborhoods voted. In suburban Cook County, the percentage was far less.

Further complicating things Tuesday could be an impending winter storm. The National Weather Service issued a warning for much of northern Illinois predicting up to 6 inches of snow. Election officials said they were communicating with streets and sanitation workers about keeping pathways to polling places clear.

"We hope the voters appreciate, that given a low turnout contest, your ballot has more power than it normally it does," said Jim Allen, spokesman for the Chicago Board of Election Commissioners.

Voters haven't seen an open primary since 1995 when Jackson first won office. His November resignation created a rare opening in the strongly Democratic territory and the Democratic winner of Tuesday's primary is expected to cruise through the April 9 election. There are 14 Democrats and four Republicans running.

The shortened campaign season has been fierce; it wasn't unusual for candidates to attend multiple debates on a single day.

While the state's most high-profile Democrats who once backed Jackson stayed out of the race, Kelly did secure union endorsements and those from other longtime U.S. Reps. Danny Davis and Bobby Rush. Also several high-profile candidates dropped out of the race: State Sen. Donne Trotter, state Sen. Toi Hutchinson and state Sen. Napoleon Harris, a former NFL player.

Although the issue of ethics has hung over the district with Jackson's legal saga in court, it's taken a back seat to guns.

Kelly, who wants an assault weapons ban, made guns her top issue, and New York City Mayor Michael Bloomberg's super PAC, Independence USA, poured more than $2 million into adds supporting her and blasting Halvorson. The ads note Halvorson once received an "A'' rating from the National Rifle Association. Halvorson supports universal background checks and gun registration but opposes a ban.

Political experts say the ads are a big factor in the race.

Political consultant Don Rose said in a race with more than a dozen candidates ? many with close positions on major issues ? the ads have been "really the only thing you can call a factor."

However, the ads could end up helping Halvorson, either drawing supporters of gun rights to the polls or with a sympathy vote from voters turned off by the negative tone.

"That's really where it's all centered," Rose said. "That spot is either going to work, or it's not ... It won't turn a loser into a winner, but in any close election it could make a difference."

Kelly says she was focused on guns long before Bloomberg's involvement and that her record in public office as a state legislator and in the Illinois treasurer's office made her well-suited for the job. She may also have another advantage: Her name is listed first on the ballot and Halvorson's is toward the bottom.

Other candidates said they're focus on a range of issues, particularly unemployment.

"I'm not a one-issue candidate," said Beale, who opened up an office south of Chicago to draw new supporters outside his city base.

Still neither candidates nor election officials were banking on a big turnout.

Tuesday's special primary coincides with municipal elections in the non-urban parts of the district. Suburban voters? areas where Halvorson has a base ? may be more motivated to get to the polls. Halvorson unsuccessfully challenged Jackson in a 2012 primary.

Chicago voter Angela Craig, a retiree, was also undecided on who to vote for but she liked Kelly's attention to guns. However, she still felt she needed more time to study the candidates and felt a little cheated with the timing of the primary, just three months after Jackson resigned.

"It's such short notice," she said, adding the congressional office is "going to take a lot of cleaning up."

__

Sophia Tareen can be reached at http://twitter.com/sophiatareen

___

Associated Press writer Sara Burnett contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-02-25-House-Jackson%20Seat/id-44ae29d0a13049c2b1331879a9197ac3

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Tuesday, February 26, 2013

First lady to press governors on veterans' jobs

New Jersey Gov. Chris Christie sits next to first lady Michelle Obama as President Barack Obama welcomed the governors of the National Governors Association to the 2013 Governors? Dinner at the White House in Washington, Sunday, Feb. 24, 2013. (AP Photo/Susan Walsh)

New Jersey Gov. Chris Christie sits next to first lady Michelle Obama as President Barack Obama welcomed the governors of the National Governors Association to the 2013 Governors? Dinner at the White House in Washington, Sunday, Feb. 24, 2013. (AP Photo/Susan Walsh)

(AP) ? First lady Michelle Obama will challenge governors to make it easier for military members to transfer their skills to civilian jobs.

Mrs. Obama wants states to pass legislation or take executive action allowing veterans to receive professional credentials or licenses based on their experiences in the military. Administration officials said that would allow veterans to apply for jobs more quickly rather than having to take courses for skills they already have.

Mrs. Obama will announce her proposals Monday during remarks to governors who are in Washington for their annual meeting. President Barack Obama and Vice President Joe Biden will also address the governors during the event at the White House.

The veterans' initiatives are part of Mrs. Obama's "Joining Forces" program, which aims to help veterans and their families. The program has focused in particular on assisting military personnel find civilian jobs, an effort that is expected to take on more urgency as more than 60,000 U.S. troops return home from Afghanistan by the end of 2014.

Mrs. Obama will ask states to focus in particular on making it easier for veterans to obtain credentials and licenses for commercial driving, nursing, and emergency medical services, administration officials said. The White House has outlined suggested legislative language states can use for implementing the changes.

Officials did not have an estimate for how much it would cost states to implement the credentialing programs. But they suggested the programs could eventually be a cost-saver by keeping veterans off unemployment.

Mrs. Obama has previously called on states to help military spouses transfer their state-specific credentials when their families move due to changes in deployment. Seventeen states have passed such legislation over the past year, joining 11 states that already had laws on the books.

The officials requested anonymity in order to speak ahead of Mrs. Obama's announcement.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-02-25-Michelle%20Obama-Veterans/id-d5f1ac08cdf8441daf29d56d8d1c98d8

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Bloomberg, Top Tech Investors Plan Virtual March For Immigration

March for InnovationNew York Mayor Michael Bloomberg and a handful of Silicon Valley's top technology investors are planning a nation-wide social media campaign to pressure congress to pass immigration reform. The so-called "virtual march" will attempt to galvanize thousands of netizens to email, tweet, and facebook their leaders to come up with a solution that solves the industry's looming skills shortage.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/rUC-RmIQqwg/

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Raul Castro Reelected as Cuba's President (Voice Of America)

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Money in politics? The sky is the limit in Mo. (The Arizona Republic)

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Source: http://enetodap.sport.fr/2013/02/24/this-in-turn-will-establish-your-sites-popularity-making-it-highly-accessible-to-interested-visitors/

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Source: http://mannmichaels.blogspot.com/2013/02/this-in-turn-will-establish-your-site.html

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Can we terminate worker to keep domestic violence from spilling ...

Q. We have learned that one of our employees has been subjected to domestic violence and has a restraining order against her boyfriend. We are concerned that the man might become violent in our workplace. We are considering terminating the employee to make sure that our other employees are safe. Does such a termination raise any legal issues?

A. Actually, the EEOC issued a guidance describing how such an action may be a form of discrimination under federal law. While the federal laws, such as Title VII and the ADA, do not directly prohibit discrimination against applicants or employees who experience domestic violence, the guidance points out that the employer?s action may be based on a sex-based or disability-based stereotype and would therefore be a form of discrimination under those laws.

The guidance provides several examples of treatment that may be based on sex-based stereotypes. One describes the firing of an employee after learning that she was subjected to domestic violence because the employer feared the potential ?drama battered women bring into the workplace.?

While the guidance does not address concerns by em??ployers for the safety of other employees, it is likely that the EEOC would conclude that the termination of the employee was based on a sex-based stereotype. Unless you have some specific information about a threat by the boyfriend to pursue the employee into the workplace, you may have difficulty showing that the decision was not based on a sex-based stereotype.

While safety of your employees is very important, you may want to think about other ways to ensure their safety.

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Monday, February 25, 2013

Oscars to movie stars: Please tweet during the awards

Matt Sayles/Invision/AP

. As part of its push to attract younger viewers to the Oscars, the Academy of Motion Picture Arts and Sciences is working to make the show a two-screen experience by offering new camera perspectives and interactive features on its website. (Photo by Matt Sayles/Invision/AP)

By Sandy Cohen, Associated Press

The Academy of Motion Picture Arts and Sciences is encouraging celebrities to tweet during the Oscars.

The film organization has expanded its digital outreach for the 85th Academy Awards with a new feature that lets stars to snap photos of themselves backstage during Sunday's ceremony and instantly post them online.

What Twitter calls a "Magic Mirror" will take photo-booth-style pictures of participating stars in the green room and send them out on the academy's official Twitter account. Organizers expect multiple celebrity mash-ups.

The backstage green room is a private place for stars to hang out before taking the stage and is typically closed to press and photographers.

The Magic Mirror is "giving access to fans at home a part of the show they never got to experience before," Twitter spokeswoman Elaine Filadelfo said Friday.

A new video-on-demand/instant replay feature also being introduced Sunday will allow Oscar fans to view show highlights online moments after they happen and share them with friends on Twitter and Facebook. Dozens of clips from the red carpet and the awards telecast will be available on the official Oscar website beyond Sunday's ceremony.

Oscar.com also offers other behind-the-scenes interactive features, including various backstage camera perspectives and a new live blog that aggregates the show's presence across social media. It will track the traffic on whatever makes a splash, like Angelina Jolie's right leg did last year.

The academy wants to make its second-screen experience just as rich as its primary one.

"Social media is now mainstream," said Christina Kounelias, chief marketing officer for the academy.

"We're not doing social media to reach out to young kids," said the academy's digital media director, Josh Spector. "We're doing it to connect with all Oscar fans."

Follow AP Entertainment Writer Sandy Cohen on Twitte.

More from TODAY and the Oscars:

Studios and promoters spend millions of dollars in the push to Oscar gold, and industry analysts say spending connected to this year's awards is higher than ever, especially when it comes to best picture. NBC's Diana Alvear reports.

?

Source: http://digitallife.today.com/_news/2013/02/24/17076052-oscars-to-movie-stars-please-tweet-during-the-awards?lite

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Return of sectarian threats in Iraq raises alarm

BAGHDAD (AP) ? The fliers began turning up at Sunni households in the Iraqi capital's Jihad neighborhood last week bearing a chilling message: Get out now or face "great agony" soon.

The leaflets were signed by the Mukhtar Army, a new Shiite militant group with ties to Iran's Revolutionary Guard. "The zero hour has come. So leave along with your families. ... You are the enemy," the messages warned.

Such overt threats all but disappeared as the darkest days of outright sectarian fighting waned in 2008 and Iraq stepped back from the brink of civil war. Their re-emergence now ? nearly a decade after the U.S.-led invasion ? is a worrying sign that rising sectarian tensions are again gnawing away at Iraqi society.

Iraqis increasingly fear that militants on both sides of the country's sectarian divide are gearing up for a new round of violence that could undo the fragile gains Iraq has made in recent years.

Members of the country's Sunni minority have been staging mass rallies for two months, with some calling for the toppling of a Shiite-led government they feel discriminates against them and is too closely allied with neighboring Iran. Sunni extremists have been stepping up large-scale attacks on predominantly Shiite targets, and concerns are growing that the brutal and increasingly sectarian fighting in Syria could spill across the border.

Many Sunnis who received the Jihad neighborhood messages are taking the warnings at face value and considering making a move.

"Residents are panicking. All of us are obsessed with these fliers," said Waleed Nadhim, a Sunni mobile phone shop owner who lives in the neighborhood. The 33-year-old father plans to leave the area because he doesn't have faith in the police to keep his family safe. "In a lawless country like Iraq, nobody can ignore threats like this."

Iraqi security forces have beefed up their presence in and around Jihad. The middle-class community, nestled along a road to the airport in southwest Baghdad, was home to Sunni civil servants and security officials under Saddam Hussein's regime, though many Shiites now live there too.

The Shiites, who are emboldened by a government and security forces dominated by their sect, have made their presence felt in Jihad in recent years. A Sunni mosque bears graffiti hailing a revered Shiite saint. A billboard on a major road shows firebrand Shiite cleric Moqtada al-Sadr flanked by a fighter gripping a machine gun.

Jihad was one of the earliest flashpoints in Baghdad's descent into sectarian bloodshed. In July 2006, the neighborhood witnessed a brazen massacre that left as many as 41 residents dead and marked an escalation in Iraq's sectarian bloodletting. In that incident, Shiite militiamen set up checkpoints to stop morning commuters, singled out Sunnis based on their names and systematically executed them in front of their Shiite neighbors.

Residents now fear the events in southwest Baghdad could be the spark for a new round of tit-for-tat killing. Two weeks ago, a Sunni and a Shiite were each killed in separate attacks in Sadiyah, next to Jihad, said a 30-year-old Sunni government employee living in the area who gave her name only as Umm Abdullah al-Taie, or mother of Abdullah.

"Nobody dares to go out after dark," she said. "People have started to hear sectarian alarm bells ringing again."

The Mukhtar Army whose named appeared on the threatening leaflets was formed by Wathiq al-Batat, a onetime senior official in the Hezbollah Brigades. He announced the creation of the new militant group earlier this month.

Hezbollah in Iraq is believed to be funded and trained by Iran's elite Revolutionary Guard and was among the Shiite militias that targeted U.S. military bases months before their December 2011 withdrawal.

Al-Batat told Iraq's al-Sharqiya channel that he formed the Mukhtar Army to confront Sunnis who might attempt to topple the government in the same way that Syrian rebels are trying to overthrow Bashar Assad's Iranian-backed regime in neighboring Syria. He said the group is advised by Iran's hard-line Quds Force, which oversees external operations of the Iranian Revolutionary Guard. He declined to say whether the group received any further support from Tehran.

Little is known about Mukhtar Army's size or capabilities. Abdullah al-Rikabi, a spokesman for the group, boasted it has 1 million members and described al-Batat as loyal to Iran's supreme leader, Ayatollah Ali Khamenei.

Iraqi Prime Minister Nouri al-Maliki's government has issued an arrest warrant against al-Batat, though he still walks free. In a speech Saturday, the Shiite premier vowed to prosecute anyone who seeks to incite sectarian strife.

The Mukhtar Army denies being behind the threats, which some Shiites believe are a ruse to tar their sect and inflame sectarian divisions.

"We have nothing to do with the fliers," said al-Rikabi, the group's spokesman. He accused members of Saddam's now-outlawed Baath party and al-Qaida of making the threats in an effort to ignite civil war.

Even though they are busy hunting down the group's leader, Iraqi authorities have their doubts about the Shiite militia's involvement in the leaflets too.

Two senior security officials said intelligence agents have obtained an al-Qaida hit list containing detailed names and residential information about people ? both Sunnis and Shiites ? living in mixed areas. They believe the group plans to target residents one by one, alternating by sect, in an effort to spread panic and suggest an atmosphere of retaliatory killings.

They spoke on condition of anonymity because they were not authorized to disclose information about security operations.

Threatening fliers from both Sunni and Shiite militias aimed at members of the opposite sect also have begun turning up in Baqouba, a former al-Qaida stronghold north of Baghdad that has a history of sectarian violence, according to Diyala provincial council member Sadiq al-Hussein.

For those living in areas where the threats turned up, their source matters less than what they portend.

Jafaar al-Fatlawi, a Shiite government employee who lives in the Jihad neighborhood, said he has started carrying a pistol with him just to answer the door and takes his family to spend the night with relatives elsewhere in the city.

"Everybody in the neighborhood expects sectarian fighting to erupt any minute," he said. "Our security forces weren't able to stop the sectarian war before and now they'll fail again."

___

Associated Press writer Sameer N. Yacoub contributed reporting.

___

Follow Adam Schreck on Twitter at http://twitter.com/adamschreck

Source: http://news.yahoo.com/return-sectarian-threats-iraq-raises-alarm-064831443.html

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Microsoft Office 2013 - caveat emptor on licensing issues!

Microsoft Corporation is an American multinational software corporation headquartered in Redmond, Washington that develops, manufactures, licenses, and supports a wide range of products and services related to computing. The company was founded by Bill Gates and Paul Allen on April 4, 1975. Microsoft is the world's largest software maker measured by revenues. It is also one of the world's most valuable companies.

Microsoft was established to develop and sell BASIC interpreters for the Altair 8800. It rose to dominate the personal computer operating system market with MS-DOS in the mid-1980s, followed by the Microsoft Windows line of operating systems. The company's 1986 initial public offering, and subsequent rise in its share price, created an estimated three billionaires and 12,000 millionaires from Microsoft employees. Since the 1990s, it has increasingly diversified from the operating system market and has made a number of corporate acquisitions. In May 2011, Microsoft acquired Skype Technologies for $8.5 billion in its largest acquisition to date.

As of 2013, Microsoft is market dominant in both the PC operating system and office suite markets (the latter with Microsoft Office). The company also produces a wide range of other software for desktops and servers, and is active in areas including internet search (with Bing), the video game industry (with the Xbox and Xbox 360 consoles), the digital services market (through MSN), and mobile phones (via the Windows Phone OS). In June 2012, Microsoft announced that it would be entering the PC vendor market for the first time, with the launch of the Microsoft Surface tablet computer.

In the 1990s, critics began to contend that Microsoft used monopolistic business practices and anti-competitive strategies including refusal to deal and tying, put unreasonable restrictions in the use of its software, and used misrepresentative marketing tactics; both the U.S. Department of Justice and European Commission found the company in violation of antitrust laws.

History

1975?83: Founding and company beginnings

Paul Allen and Bill Gates, childhood friends with a passion in computer programming, were seeking to make a successful business utilizing their shared skills. The January 1975 issue of Popular Electronics featured Micro Instrumentation and Telemetry Systems's (MITS) Altair 8800 microcomputer. Allen noticed that they could program a BASIC interpreter for the device; after a call from Gates claiming to have a working interpreter, MITS requested a demonstration. Since they didn't actually have one, Allen worked on a simulator for the Altair while Gates developed the interpreter. Although they developed the interpreter on a simulator and not the actual device, the interpreter worked flawlessly when they demonstrated the interpreter to MITS in Albuquerque, New Mexico in March 1975; MITS agreed to distribute it, marketing it as Altair BASIC. They officially established Microsoft on April 4, 1975, with Gates as the CEO. Allen came up with the original name of "Micro-Soft," as recounted in a 1995 Fortune magazine article. In August 1977 the company formed an agreement with ASCII Magazine in Japan, resulting in its first international office, "ASCII Microsoft". The company moved to a new home in Bellevue, Washington in January 1979.

Microsoft entered the OS business in 1980 with its own version of Unix, called Xenix. However, it was MS-DOS that solidified the company's dominance. After negotiations with Digital Research failed, IBM awarded a contract to Microsoft in November 1980 to provide a version of the CP/M OS, which was set to be used in the upcoming IBM Personal Computer (IBM PC). For this deal, Microsoft purchased a CP/M clone called 86-DOS from Seattle Computer Products, branding it as MS-DOS, which IBM rebranded to PC-DOS. Following the release of the IBM PC in August 1981, Microsoft retained ownership of MS-DOS. Since IBM copyrighted the IBM PC BIOS, other companies had to reverse engineer it in order for non-IBM hardware to run as IBM PC compatibles, but no such restriction applied to the operating systems. Due to various factors, such as MS-DOS's available software selection, Microsoft eventually became the leading PC operating systems vendor. The company expanded into new markets with the release of the Microsoft Mouse in 1983, as well as a publishing division named Microsoft Press. Paul Allen resigned from Microsoft in February after developing Hodgkin's disease.

1984?94: Windows and Office

While jointly developing a new OS with IBM in 1984, OS/2, Microsoft released Microsoft Windows, a graphical extension for MS-DOS, on November 20. Microsoft moved its headquarters to Redmond on February 26, 1986, and on March 13 the company went public; the ensuing rise in the stock would make an estimated four billionaires and 12,000 millionaires from Microsoft employees. Due to the partnership with IBM, in 1990 the Federal Trade Commission set its eye on Microsoft for possible collusion; it marked the beginning of over a decade of legal clashes with the U.S. Government. Microsoft announced the release of its version of OS/2 to original equipment manufacturers (OEMs) on April 2, 1987; meanwhile, the company was at work on a 32-bit OS, Microsoft Windows NT, using ideas from OS/2; it shipped on July 21, 1993 with a new modular kernel and the Win32 application programming interface (API), making porting from 16-bit (MS-DOS-based) Windows easier. Once Microsoft informed IBM of NT, the OS/2 partnership deteriorated.

In 1990, Microsoft introduced its office suite, Microsoft Office. The software bundled separate office productivity applications, such as Microsoft Word and Microsoft Excel. On May 22 Microsoft launched Windows 3.0 with a streamlined user interface graphics and improved protected mode capability for the Intel 386 processor. Both Office and Windows became dominant in their respective areas. Novell, a Word competitor from 1984?1986, filed a lawsuit years later claiming that Microsoft left part of its APIs undocumented in order to gain a competitive advantage.

On July 27, 1994, the U.S. Department of Justice, Antitrust Division filed a Competitive Impact Statement that said, in part: "Beginning in 1988, and continuing until July 15, 1994, Microsoft induced many OEMs to execute anti-competitive "per processor" licenses. Under a per processor license, an OEM pays Microsoft a royalty for each computer it sells containing a particular microprocessor, whether the OEM sells the computer with a Microsoft operating system or a non-Microsoft operating system. In effect, the royalty payment to Microsoft when no Microsoft product is being used acts as a penalty, or tax, on the OEM's use of a competing PC operating system. Since 1988, Microsoft's use of per processor licenses has increased."

1995?2005: Internet and the 32-bit era

1993 took over from the Federal Trade Commission, a protracted legal wrangling between Microsoft and the department ensued, resulting in various settlements and possible blocked mergers. Microsoft would point to companies such as AOL-Time Warner in its defense.]]

Following Bill Gates's internal "Internet Tidal Wave memo" on May 26, 1995, Microsoft began to redefine its offerings and expand its product line into computer networking and the World Wide Web. The company released Windows 95 on August 24, 1995, featuring pre-emptive multitasking, a completely new user interface with a novel start button, and 32-bit compatibility; similar to NT, it provided the Win32 API. Windows 95 came bundled with the online service MSN, and for OEMs Internet Explorer, a web browser. Internet Explorer was not bundled with the retail Windows 95 boxes because the boxes were printed before the team finished the web browser, and instead was included in the Windows 95 Plus! pack. Branching out into new markets in 1996, Microsoft and NBC Universal created a new 24/7 cable news station, MSNBC. Microsoft created Windows CE 1.0, a new OS designed for devices with low memory and other constraints, such as personal digital assistants. In October 1997, the Justice Department filed a motion in the Federal District Court, stating that Microsoft violated an agreement signed in 1994 and asked the court to stop the bundling of Internet Explorer with Windows.

Bill Gates handed over the CEO position on January 13, 2000 to Steve Ballmer, an old college friend of Gates and employee of the company since 1980, creating a new position for himself as Chief Software Architect. Various companies including Microsoft formed the Trusted Computing Platform Alliance in October 1999 to, among other things, increase security and protect intellectual property through identifying changes in hardware and software. Critics decry the alliance as a way to enforce indiscriminate restrictions over how consumers use software, and over how computers behave, a form of digital rights management; for example the scenario where a computer is not only secured for its owner, but also secured against its owner as well. On April 3, 2000, a judgment was handed down in the case of United States v. Microsoft, calling the company an "abusive monopoly"; it settled with the U.S. Department of Justice in 2004. On October 25, 2001 Microsoft released Windows XP, unifying the mainstream and NT lines under the NT codebase. The company released the Xbox later that year, entering the game console market dominated by Sony and Nintendo. In March 2004 the European Union brought antitrust legal action against the company, citing it abused its dominance with the Windows OS, resulting in a judgment of ?497million ($613million) and to produce new versions of Windows XP without Windows Media Player, Windows XP Home Edition N and Windows XP Professional N.

2006?10: Windows Vista, mobile, and Windows 7

Released in January 2007, the next version of Windows, Windows Vista, focused on features, security, and a redesigned user interface dubbed Aero. Microsoft Office 2007, released at the same time, featured a "Ribbon" user interface which was a significant departure from its predecessors. Relatively strong sales of both titles helped to produce a record profit in 2007. The European Union imposed another fine of ?899million ($1.4billion) for Microsoft's lack of compliance with the March 2004 judgment on February 27, 2008, saying that the company charged rivals unreasonable prices for key information about its workgroup and backoffice servers. Microsoft stated that it was in compliance and that "these fines are about the past issues that have been resolved".

Bill Gates retired from his role as Chief Software Architect on June 27, 2008 while retaining other positions related to the company in addition to being an advisor for the company on key projects. Azure Services Platform, the company's entry into the cloud computing market for Windows, launched on October 27, 2008. On February 12, 2009, Microsoft announced its intent to open a chain of Microsoft-branded retail stores, and on October 22, 2009 the first retail Microsoft Store opened in Scottsdale, Arizona; the same day the first store opened Windows 7 was officially released to the public. Windows 7's focus was on refining Vista with ease of use features and performance enhancements, rather than a large reworking of Windows.

As the smartphone industry boomed beginning in 2007, Microsoft struggled to keep up with its rivals Apple and Google in providing a modern smartphone operating system. As a result, in 2010, Microsoft revamped their aging flagship mobile operating system, Windows Mobile, replacing it with the new Windows Phone OS; along with a new strategy in the smartphone industry that has Microsoft working more closely with smartphone manufactures, such as Nokia, and to provide a consistent user experience across all smartphones using Microsoft's Windows Phone OS. It used a new user interface design language, codenamed "Metro", which prominently used simple shapes, typography and iconography, and the concept of minimalism.

Microsoft is a founding member of the Open Networking Foundation started on March 23, 2011. Other founding companies include Google, HP Networking, Yahoo, Verizon, Deutsche Telekom and 17 other companies. The nonprofit organization is focused on providing support for a new cloud computing initiative called Software-Defined Networking. The initiative is meant to speed innovation through simple software changes in telecommunications networks, wireless networks, data centers and other networking areas.

2011?present: Rebranding, Windows 8, and Surface

Following the release of Windows Phone 7, Microsoft underwent a gradual rebranding of its product range throughout 2011 and 2012. Its logos, products, services, and websites adopted the principles and concepts of the Metro design language. Microsoft previewed Windows 8 in Taipei in June 2011. The operating system was designed to power both personal computers and tablet computers. A developer preview was released on September 13, and was replaced by a consumer preview on February 29, 2012. On May 31, 2012, the release preview version was released. On June 18, Microsoft announced the Microsoft Surface, the first computer in the company's history to have its hardware made by Microsoft themselves. On June 25, Microsoft announced that it was paying $1.2 billion to buy the social network Yammer. On July 31, 2012, Microsoft launched the Outlook.com webmail service to compete with Gmail. On September 4, Microsoft released Windows Server 2012. On October 1, Microsoft announced it is launching a news operation when Windows 8 launches later in the month. It is part of a new-look MSN. On October 26, Microsoft launched Windows 8 and the Microsoft Surface. Three days later, it launched Windows Phone 8. To cope with the potential increase in demand for products and services, Microsoft opened a number of "holiday stores" across the US to complement the ever-growing increase of bricks and mortar Microsoft Stores that have been sprouting up in 2012.

Product divisions

For the 2010 fiscal year, Microsoft had five product divisions: Windows Division, Server and Tools, Online Services Division, Microsoft Business Division, and Entertainment and Devices Division.

Windows Division, Server and Tools, Online Services Division

The company's Client division produces the flagship Windows OS line such as Windows 7; it also produces the Windows Live family of products and services. Server and Tools produces the server versions of Windows, such as Windows Server 2008 R2 as well as a set of development tools called Microsoft Visual Studio, Microsoft Silverlight, a web application framework, and System Center Configuration Manager, a collection of tools providing remote-control abilities, patch management, software distribution and a hardware/software inventory. Other server products include: Microsoft SQL Server, a relational database management system, Microsoft Exchange Server, for certain business-oriented e-mail and scheduling features, Small Business Server, for messaging and other small business-oriented features; and Microsoft BizTalk Server, for business process management.

Microsoft provides IT consulting ("Microsoft Consulting Services") and produces a set of certification programs handled by the Server and Tools division designed to recognize individuals who have a minimal set of proficiencies in a specific role; this includes developers ("Microsoft Certified Solution Developer"), system/network analysts ("Microsoft Certified Systems Engineer"), trainers ("Microsoft Certified Trainers") and administrators ("Microsoft Certified Systems Administrator" and "Microsoft Certified Database Administrator"). Microsoft Press, which publishes books, is also managed by the division. The Online Services Business division handles the online service MSN and the search engine Bing. As of December 2009, the company also possesses an 18% ownership of the cable news channel MSNBC without any editorial control; however, the division develops the channel's website, msnbc.com, in a joint venture with the channel's co-owner, NBC Universal.

Business Division

The Microsoft Business Division produces Microsoft Office including Microsoft Office 2010, the company's line of office software. The software product includes Word (a word processor), Access (a relational database program), Excel (a spreadsheet program), Outlook (Groupware, frequently used with Exchange Server), PowerPoint (presentation software), Publisher (desktop publishing software) and Sharepoint. A number of other products were added later with the release of Office 2003 including Visio, Project, MapPoint, InfoPath and OneNote. The division also develops enterprise resource planning (ERP) software for companies under the Microsoft Dynamics brand. These include: Microsoft Dynamics AX, Microsoft Dynamics NAV, Microsoft Dynamics GP, and Microsoft Dynamics SL. They are targeted at varying company types and countries, and limited to organizations with under 7,500 employees. Also included under the Dynamics brand is the customer relationship management software Microsoft Dynamics CRM, part of the Azure Services Platform.

Entertainment and Devices Division

The Entertainment and Devices Division produces the Windows CE OS for embedded systems and Windows Phone for smartphones. Microsoft initially entered the mobile market through Windows CE for handheld devices, eventually developing into the Windows Mobile OS and now, Windows Phone. Windows CE is designed for devices where the OS may not directly be visible to the end user, in particular, appliances and cars. The division also produces computer games that run on Windows PCs and other systems including titles such as Age of Empires, Halo and the Microsoft Flight Simulator series, and houses the Macintosh Business Unit which produces Mac OS software including Microsoft Office 2011 for Mac. Microsoft's Entertainment and Devices Division designs, markets, and manufactures consumer electronics including the Xbox 360 game console, the handheld Zune media player, and the television-based Internet appliance MSN TV. Microsoft also markets personal computer hardware including mice, keyboards, and various game controllers such as joysticks and gamepads.

Culture

Technical reference for developers and articles for various Microsoft magazines such as Microsoft Systems Journal (or MSJ) are available through the Microsoft Developer Network (MSDN). MSDN also offers subscriptions for companies and individuals, and the more expensive subscriptions usually offer access to pre-release beta versions of Microsoft software. In April 2004 Microsoft launched a community site for developers and users, titled Channel9, that provides a wiki and an Internet forum. Another community site that provides daily videocasts and other services, On10.net, launched on March 3, 2006. Free technical support is traditionally provided through online Usenet newsgroups, and CompuServe in the past, monitored by Microsoft employees; there can be several newsgroups for a single product. Helpful people can be elected by peers or Microsoft employees for Microsoft Most Valuable Professional (MVP) status, which entitles them to a sort of special social status and possibilities for awards and other benefits.

Noted for its internal lexicon, the expression "eating our own dog food" is used to describe the policy of using prerelease and beta versions of products inside Microsoft in an effort to test them in "real-world" situations. This is usually shortened to just "dog food" and is used as noun, verb, and adjective. Another bit of jargon, FYIFV or FYIV ("Fuck You, I'm [Fully] Vested"), is used by an employee to indicate they are financially independent and can avoid work anytime they wish. The company is also known for its hiring process, mimicked in other organizations and dubbed the "Microsoft interview", which is notorious for off-the-wall questions such as "Why is a manhole cover round?".

Microsoft is an outspoken opponent of the cap on H1B visas, which allow companies in the U.S. to employ certain foreign workers. Bill Gates claims the cap on H1B visas makes it difficult to hire employees for the company, stating "I'd certainly get rid of the H1B cap" in 2005. Critics of H1B visas argue that relaxing the limits would result in increased unemployment for U.S. citizens due to H1B workers working for lower salaries. The Human Rights Campaign Corporate Equality Index, a report of how progressive the organization deems company policies towards LGBT (lesbian, gay, bisexual and transsexual) employees, rated Microsoft as 87% from 2002 to 2004 and as 100% from 2005 to 2010 after they allowed gender expression.

Criticism

Criticism of Microsoft has followed the company's existence because of various aspects of its products and business practices. Ease of use, stability, and security of the company's software are common targets for critics. More recently, Trojan horses and other exploits have plagued numerous users due to faults in the security of Microsoft Windows and other programs. Microsoft is also accused of locking vendors into their products, and not following and complying with existing standards in its software. Total cost of ownership comparisons of Linux as well as Mac OS X to Windows are a continuous point of debate.

The company has been in numerous lawsuits by several governments and other companies for unlawful monopolistic practices. In 2004, the European Union found Microsoft guilty in a highly publicized anti-trust case. Additionally, Microsoft's EULA for some of its programs is often criticized as being too restrictive as well as being against open source software.

Microsoft has been criticized (along with Yahoo, AOL, and other companies) for its involvement in censorship in the People's Republic of China. Microsoft has also come under criticism for outsourcing jobs to China and India. There were reports of poor working conditions at a factory in southern China that makes some of Microsoft's products.

Corporate affairs

The company is run by a board of directors made up of mostly company outsiders, as is customary for publicly traded companies. Members of the board of directors as of June 2010 are: Steve Ballmer, Dina Dublon, Bill Gates (chairman), Raymond Gilmartin, Reed Hastings, Maria Klawe, David Marquardt, Charles Noski, and Helmut Panke. Board members are elected every year at the annual shareholders' meeting using a majority vote system. There are five committees within the board which oversee more specific matters. These committees include the Audit Committee, which handles accounting issues with the company including auditing and reporting; the Compensation Committee, which approves compensation for the CEO and other employees of the company; the Finance Committee, which handles financial matters such as proposing mergers and acquisitions; the Governance and Nominating Committee, which handles various corporate matters including nomination of the board; and the Antitrust Compliance Committee, which attempts to prevent company practices from violating antitrust laws.

When Microsoft went public and launched its initial public offering (IPO) in 1986, the opening stock price was $21; after the trading day, the price closed at $27.75. As of July 2010, with the company's nine stock splits, any IPO shares would be multiplied by 288; if one was to buy the IPO today given the splits and other factors, it would cost about 9cents. The stock price peaked in 1999 at around $119 ($60.928 adjusting for splits). The company began to offer a dividend on January 16, 2003, starting at eight cents per share for the fiscal year followed by a dividend of sixteen cents per share the subsequent year, switching from yearly to quarterly dividends in 2005 with eight cents a share per quarter and a special one-time payout of three dollars per share for the second quarter of the fiscal year. Though the company had subsequent increases in dividend payouts, the price of Microsoft's stock remained steady for years.

One of Microsoft's business tactics, described by an executive as "embrace, extend and extinguish," initially embraces a competing standard or product, then extends it to produce their own version which is then incompatible with the standard, which in time extinguishes competition that does not or cannot use Microsoft's new version. Various companies and governments sue Microsoft over this set of tactics, resulting in billions of dollars in rulings against the company. Microsoft claims that the original strategy is not anti-competitive, but rather an exercise of its discretion to implement features it believes customers want.

Financial

Standard and Poor's and Moody's have both given a AAA rating to Microsoft, whose assets were valued at $41?billion as compared to only $8.5?billion in unsecured debt. Consequently, in February 2011 Microsoft released a corporate bond amounting to $2.25?billion with relatively low borrowing rates compared to government bonds.

For the first time in 20 years Apple Inc. surpassed Microsoft in Q1 2011 quarterly profits and revenues due to a slowdown in PC sales and continuing huge losses in Microsoft's Online Services Division (which contains its search engine Bing). Microsoft profits were $5.2 billion, while Apple Inc. profits were $6 billion, on revenues of $14.5 billion and $24.7 billion respectively.

Microsoft's Online Services Division has been continuously loss-making since 2006 and in Q1 2011 it lost $726 million. This follows a loss of $2.5 billion for the year 2010.

On July 20, 2012, Microsoft posted its first quarterly loss ever, despite earning record revenues for the quarter and fiscal year. Microsoft reported a net loss of $492 million; the 2007 acquisition of advertising company aQuantive for $6.2 billion and problems associated with it have been cited as the cause.

Environment

Microsoft is ranked on the 17th place in Greenpeace's Guide to Greener Electronics (16th Edition) that ranks 18 electronics manufacturers according to their policies on toxic chemicals, recycling and climate change. Microsoft's timeline for phasing out BFRs and phthalates in all products is 2012 but its commitment to phasing out PVC is not clear. As yet (January 2011) it has no products that are completely free from PVC and BFRs.

Microsoft's main U.S. campus received a silver certification from the Leadership in Energy and Environmental Design (LEED) program in 2008, and it installed over 2,000 solar panels on top of its buildings in its Silicon Valley campus, generating approximately 15 percent of the total energy needed by the facilities in April 2005.

Microsoft makes use of alternative forms of transit. It created one of the worlds largest private bus systems, the "Connector", to transport people from outside the company; for on-campus transportation, the "Shuttle Connect" uses a large fleet of hybrid cars to save fuel. The company also subsidises regional public transport as an incentive. In February 2010 however, Microsoft took a stance against adding additional public transport and high-occupancy vehicle (HOV) lanes to a bridge connecting Redmond to Seattle; the company did not want to delay the construction any further.

Microsoft was ranked number 1 in the list of the World's Best Multinational Workplaces by the Great Place to Work Institute in 2011.

Marketing

In 2004, Microsoft commissioned research firms to do independent studies comparing the total cost of ownership (TCO) of Windows Server 2003 to Linux; the firms concluded that companies found Windows easier to administrate than Linux, thus those using Windows would administrate faster resulting in lower costs for their company (i.e. lower TCO). This spurred a wave of related studies; a study by the Yankee Group concluded that upgrading from one version of Windows Server to another costs a fraction of the switching costs from Windows Server to Linux, although companies surveyed noted the increased security and reliability of Linux servers and concern about being locked into using Microsoft products. Another study, released by the Open Source Development Labs, claimed that the Microsoft studies were "simply outdated and one-sided" and their survey concluded that the TCO of Linux was lower due to Linux administrators managing more servers on average and other reasons.

As part of the "Get the Facts" campaign Microsoft highlighted the .NET trading platform that it had developed in partnership with Accenture for the London Stock Exchange, claiming that it provided "five nines" reliability. After suffering extended downtime and unreliability the LSE announced in 2009 that it was planning to drop its Microsoft solution and switch to a Linux based one in 2010.

Logo

Microsoft adopted the so-called "Pac-Man Logo", designed by Scott Baker, in 1987. Baker stated "The new logo, in Helvetica italic typeface, has a slash between the o and s? to emphasize the "soft" part of the name and convey motion and speed." Dave Norris ran an internal joke campaign to save the old logo, which was green, in all uppercase, and featured a fanciful letter O, nicknamed the blibbet, but it was discarded. Microsoft's logo with the "Your potential. Our passion." tagline below the main corporate name, is based on a slogan Microsoft used in 2008. In 2002, the company started using the logo in the United States and eventually started a TV campaign with the slogan, changed from the previous tagline of "Where do you want to go today?". During the private MGX (Microsoft Global Exchange) conference in 2010, Microsoft unveiled the company's next tagline, "Be What's Next.".

On August 23, 2012, Microsoft unveiled a new corporate logo at the opening of its 23rd Microsoft store in Boston indicating the company's shift of focus from the classic style to the tile-centric modern interface which it uses/will use on the Windows Phone platform, Xbox 360, Windows 8 and the upcoming Office Suites. The new logo also includes four squares with the colors of the then-current Windows logo. This logo is, however, not completely new - it was featured in Windows 95 commercials from the mid-90s. Moreover it resembles the new logo of DVDVideoSoft, which was introduced several months prior the new Microsoft's logo.

File:Microsoft - Where do you want to go today.svg|Microsoft "Pac-Man" logo, designed by Scott Baker and used from 1987 to 2012 with the 1994?2002 slogan "Where do you want to go today?". File:Microsoft logo & slogan.svg|Microsoft logo as of 2006?2011, with the slogan "Your potential. Our passion." File:The Microsoft logo & slogan.png|Logo by Microsoft with the slogan"Be What's Next." 2011?2012. File:Microsoft.svg|Introduced on August 23, 2012 to symbolize the "world of digital motion" and Microsoft's "diverse portfolio of products." 2012-present .

See also

  • List of Microsoft topics
  • References

    External links

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    Source: http://article.wn.com/view/2013/02/24/Microsoft_Office_2013_caveat_emptor_on_licensing_issues/

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